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Updated: May 22, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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Functions of FGF21 and its role in cardiac hypertrophy

Lei Chen1, Meng Gao1, Sang-Bing Ong2

  • 1Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China; Institute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

Journal of Advanced Research
|March 15, 2025
PubMed
Abstract

Insights

Fibroblast Growth Factor 21 (FGF21) shows promise in treating cardiac hypertrophy by regulating metabolism and stress pathways. Further research is needed to overcome limitations in clinical applications.

Area of Science:

  • Cardiovascular Biology
  • Endocrinology
  • Molecular Medicine

Background:

  • Fibroblast Growth Factor 21 (FGF21) is a hormone induced by stress.
  • FGF21 expression is elevated in cardiac hypertrophy, offering protection against heart injury.
  • Current preclinical and clinical applications of FGF21 for cardiac hypertrophy are limited.

Purpose of the Study:

  • To review the multifaceted roles of FGF21.
  • To explore the connection between FGF21 functions and cardiac hypertrophy.
  • To discuss challenges and future directions for FGF21-based therapies.

Main Methods:

  • Literature review of FGF21 functions.
  • Analysis of FGF21's regulatory mechanisms in cardiac hypertrophy.
  • Synthesis of current research on FGF21 and heart disease.

Main Results:

  • FGF21 influences energy metabolism, inflammation, oxidative stress, apoptosis, and autophagy.
  • FGF21 regulates cardiac hypertrophy initiation and progression via these pathways.
  • FGF21 demonstrates potential therapeutic benefits for cardiac hypertrophy.

Conclusions:

  • FGF21 plays a significant role in modulating key cellular processes relevant to cardiac hypertrophy.
  • Understanding FGF21's mechanisms offers insights into novel therapeutic strategies.
  • FGF21 represents a promising candidate for treating cardiac hypertrophy.
Keywords:
ApoptosisAutophagyCardiac hypertrophyEnergy metabolismFGF21InflammationOxidative stress

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