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Updated: May 22, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Melanoma in pregnancy.

Christina S Oh¹, Elizabeth F Sher¹, Amy K Bieber¹

¹The Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY, USA.

Seminars in Perinatology

|March 15, 2025

Summary

Pregnancy does not appear to worsen outcomes for cutaneous melanoma (skin cancer). Advanced melanoma during pregnancy presents unique challenges, requiring multidisciplinary management strategies.

Keywords:

malignancy malignant melanoma melanoma pregnancy pregnancy-associated malignancy pregnancy-associated melanoma

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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Published on: September 7, 2013

Area of Science:

Dermatology
Obstetrics & Gynecology
Oncology

Background:

Cutaneous melanoma is a significant malignancy in women of childbearing age, comprising a substantial portion of cancers during pregnancy.
The physiological changes during pregnancy and their impact on melanoma pathophysiology are not fully understood.
Melanoma during gestation requires careful consideration due to potential maternal and fetal implications.

Purpose of the Study:

To review current literature on cutaneous melanoma in pregnant patients.
To highlight diagnostic clinical pearls for melanoma in this population.
To outline multidisciplinary management strategies for advanced melanoma during pregnancy.

Main Methods:

Comprehensive review of existing scientific literature on melanoma and pregnancy.
Analysis of clinical presentations and diagnostic challenges.
Synthesis of management recommendations from available studies.

Main Results:

Pregnancy does not seem to adversely affect maternal outcomes for cutaneous melanoma.
Serious obstetric or fetal complications are rare, excluding placental and fetal metastases.
Localized melanoma treatment aligns with general population guidelines; advanced cases pose management challenges.

Conclusions:

Melanoma in pregnancy generally has favorable maternal outcomes.
Advanced melanoma during pregnancy necessitates specialized, multidisciplinary care approaches.
Further research is needed to establish unified management recommendations for advanced melanoma in pregnant patients.