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Updated: May 22, 2025
08:19
Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
16.0K
Lymphoma and leukemia occurring during pregnancy.
Adam S Zayac1, Ogechukwu Egini1, Neil D Palmisiano1
1Division of Blood Disorders, Rutgers Cancer Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Seminars in Perinatology
|March 15, 2025
Summary
Managing hematologic malignancies during pregnancy is complex due to intensive chemotherapy needs. This review provides guidelines for diagnosing and treating cancers like leukemia and lymphoma, balancing maternal and fetal health.
Area of Science:
- Hematology
- Oncology
- Maternal-Fetal Medicine
- Gynecologic Oncology
Background:
- Malignancies during pregnancy are rare, with limited data on optimal management strategies.
- Hematologic malignancies often require multiagent cytotoxic chemotherapy, posing unique challenges during pregnancy compared to solid tumors.
- Managing these cancers necessitates close collaboration among obstetricians, maternal-fetal medicine specialists, and oncologists.
Purpose of the Study:
- To review current guidelines and clinical experience for managing hematologic malignancies in pregnant patients.
- To discuss diagnostic approaches and therapeutic schemes for various hematologic cancers during pregnancy.
- To provide guidance on decision-making, weighing maternal and fetal risks and benefits of different treatment modalities.
Main Methods:
- Review of published guidelines from interdisciplinary expert panels.
- Synthesis of available data and clinical experience on managing pregnancy-associated hematologic malignancies.
- Discussion of diagnostic and therapeutic strategies, including chemotherapy, cellular therapies, immunotherapies, and targeted agents.
Main Results:
- Hematologic malignancies during pregnancy require specialized, multidisciplinary care.
- Optimal management involves careful consideration of diagnostic accuracy and therapeutic efficacy.
- Treatment decisions must balance maternal and fetal well-being, utilizing a range of therapeutic options.
Conclusions:
- Effective management of Hodgkin lymphoma, non-Hodgkin lymphomas, acute leukemias, and chronic leukemias during pregnancy is achievable with coordinated care.
- Guidelines emphasize a risk-benefit analysis for all diagnostic and therapeutic interventions.
- Continued research and data collection are crucial for refining management protocols for these rare conditions.
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