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Immune-neuroendocrine interactions.

H O Besedovsky, A E del Rey, E Sorkin

    Journal of Immunology (Baltimore, Md. : 1950)
    |August 1, 1985
    PubMed
    Summary

    The immune response influences brain and endocrine functions through soluble factors. These interactions modify immune cell microenvironments, impacting immune regulation.

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    Area of Science:

    • Immunology
    • Neuroendocrinology
    • Psychoneuroimmunology

    Background:

    • Immune responses trigger significant changes in the endocrine and autonomic nervous systems.
    • These neuroendocrine alterations are mediated by signaling molecules released from immune cells.

    Purpose of the Study:

    • To explore the intricate relationship between immune system activation and neuroendocrine responses.
    • To elucidate the mechanisms by which immune cells influence the nervous and endocrine systems.

    Main Methods:

    • Review of existing literature on immune-neuroendocrine interactions.
    • Analysis of signaling pathways involving soluble factors from activated immune cells.

    Main Results:

    • Immune responses induce functional changes in the brain and endocrine system.
    • Soluble factors from immune cells modulate neurotransmitter, hormone, and neuropeptide levels.
    • These modifications create external signals that influence immune cell autoregulation.

    Conclusions:

    • Immune-neuroendocrine interactions represent a critical bidirectional communication pathway.
    • Understanding these interactions is key to comprehending the regulation of immune responses.
    • Modulation of the neuroendocrine milieu by immune factors plays a vital role in overall physiological balance.

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