Related Experiment Video

Updated: Jun 14, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Current androgen receptor antagonists under investigation for resistant prostate cancer: progress and challenges

Linda Danielli1,2, Elisa Tassinari1,2, Andrea Marchetti1,2

  • 1Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Expert Review of Anticancer Therapy
|March 16, 2025
PubMed
Abstract

Insights

Second-generation androgen receptor signaling inhibitors (ARSIs) are key in treating castration-resistant prostate cancer. Research explores ARSI combinations and resistance mechanisms to improve patient outcomes and overcome treatment challenges.

Area of Science:

  • Oncology
  • Urology
  • Pharmacology

Background:

  • Prostate cancer progression is driven by androgen receptor (AR) signaling.
  • Treatment resistance necessitates advanced therapies for castration-resistant prostate cancer (CRPC).

Purpose of the Study:

  • To analyze the role of second-generation ARSI in CRPC management.
  • To examine combination strategies and resistance mechanisms.
  • To provide insights into future treatment directions.

Main Methods:

  • PubMed literature research on CRPC treatments.
  • Analysis of relevant clinical trials and reviews.

Main Results:

  • ARSIs have significantly improved CRPC management.
  • Challenges include treatment sequencing, resistance, and personalized therapy.

Conclusions:

  • Biomarker-driven approaches are crucial for patient selection and outcomes.
  • Ongoing trials focus on novel agents and combinations to enhance treatment efficacy.
Keywords:
Androgen receptorPARPiPSMAandrogen-receptor signaling inhibitorscastration-resistant prostate cancercombination therapydrug resistancemCRPC

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