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Lung Capacity

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.

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Related Experiment Video

Updated: May 22, 2025

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

Circulating CC16, immune response to Mycoplasma pneumoniae and lung function: a population-based, multi-cohort study.

Alane Blythe C Dy¹, Nipasiri Voraphani¹, Amber Spangenberg¹

¹Asthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, AZ, USA.

Respiratory Medicine

|March 16, 2025

Summary

Low club cell secretory protein (CC16) levels combined with Mycoplasma pneumoniae (Mp) infection history may worsen lung function in asthma patients. This highlights potential risks for airflow limitation in susceptible individuals.

Keywords:

Asthma CC16 Mycoplasma pneumoniae lung function

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Last Updated: May 22, 2025

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

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Published on: September 19, 2016

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

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Published on: August 7, 2017

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

Area of Science:

Pulmonary Medicine
Immunology
Respiratory Health

Background:

Club cell secretory protein (CC16) is crucial for protecting lung function and modulating inflammatory responses.
Low CC16 levels and increased susceptibility to Mycoplasma pneumoniae (Mp) infection are observed in individuals with asthma.
The combined impact of low CC16 and Mp seropositivity on lung function deficits, particularly airflow limitation in asthma, requires investigation.

Purpose of the Study:

To determine the combined effects of low CC16 levels and Mp seropositivity on lung function deficits.
To assess the predisposition to airflow limitation, especially in individuals with asthma.

Main Methods:

Serum CC16 and Mp-specific IgG antibodies (MpIgG) were measured in adult participants from multiple cohorts.
Participants were categorized into four groups based on CC16 levels and MpIgG status.
Linear regression and meta-analysis were used to assess associations between these groups and lung function (FEV1, FEV1/FVC).

Main Results:

Low CC16 levels were associated with decreased lung function in the overall population.
No combined effects of CC16 and MpIgG were found in the total population.
In asthmatic participants, low CC16 with Mp seropositivity correlated with significantly lower FEV1/FVC z-scores, indicating airflow limitation.

Conclusions:

Individuals with asthma and low CC16 levels, coupled with a history of Mp infection, may face heightened susceptibility to airflow limitation.
These findings underscore the importance of CC16 and Mp infection history in asthma-related lung function deficits.
Further prospective studies are recommended to validate these observations and explore therapeutic strategies.