Related Experiment Video
Updated: May 22, 2025
07:50
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
15.7K
Cutaneous Arteritis Complicated by Crohn's Disease
Takao Nagashima1, Hiroki Yabe1, Naoka Umemoto2
1Division of Rheumatology, First Department of Integrated Medicine, Jichi Medical University Saitama Medical Center, Japan.
Internal Medicine (Tokyo, Japan)
|March 16, 2025
Summary
Cutaneous arteritis, a rare Crohn
Area of Science:
- Gastroenterology
- Dermatology
- Rheumatology
Background:
- Cutaneous arteritis (CA) is an uncommon manifestation of Crohn's disease (CD).
- Systemic involvement of CA is rarely documented.
- CD is a chronic inflammatory bowel disease affecting the gastrointestinal tract.
Purpose of the Study:
- To report a rare case of systemic evolution of cutaneous arteritis in a patient with Crohn's disease.
- To highlight the diagnostic challenges and management considerations for systemic CA.
Main Methods:
- Case report of a 50-year-old woman with a 15-year history of CA.
- Clinical presentation: fever, abdominal pain, hematochezia, elevated C-reactive protein.
- Diagnostic procedures: emergency colonoscopy, histopathological examination of colonic biopsies.
Main Results:
- Colonoscopy revealed longitudinal ulcers, indicative of Crohn's disease.
- Histopathology confirmed epithelioid granulomas, establishing the diagnosis of Crohn's disease.
- The patient received intravenous prednisolone treatment.
Conclusions:
- Systemic manifestations in patients with cutaneous arteritis warrant thorough investigation for underlying conditions like Crohn's disease.
- Early diagnosis and appropriate management are crucial for improving patient outcomes.
- This case underscores the importance of considering systemic comorbidities in patients presenting with atypical symptoms of CA.
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
151
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
151
01:17Chronic Bowel Disorders: Introduction
375
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
375
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
290
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
290
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
106
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
106
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
126
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
126
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
107
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
107