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Prognostic factors for survival after allogeneic transplantation in acute myeloid leukemia in Iran using censored

Maryam Tatari1, Amir Kasaeian2,3,4, Amir-Hossein Mousavian5,6

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Scientific Reports
|March 17, 2025
PubMed

Hematopoietic stem cell transplantation (HSCT) emerged over sixty years ago as a groundbreaking and potentially curative treatment for patients with acute myeloid leukemia (AML) who were not responding to chemotherapy. In this study, we aimed to investigate prognostic factors for survival after allo-HSCT in AML patients. This retrospective cohort study was carried out using data from 742 adult AML patients underwent allo-HSCT. we analysis prognostic factors for survival after allo-HSCT with censored quantile regression model. The 5-year OS, DFS and GRFS rates were 58, 53, and 30%, respectively. OS for recipients older than 35 years was 0.95 and 1.12 years lower than that for recipients under 35 years in the 25th and 40th percentiles, respectively. Compared to patients in their CRІ, those with CRІІІ disease experienced a decrease in OS at the 25th and 40th percentiles by 1.72 and 3.72 years, respectively. Moreover, OS for ABO matched patients was 0.92 and 1.29 years longer than that of patients with an ABO major mismatch. This study could assist oncologists and hematologists in understanding the prognostic factors affecting patient survival across various survival ranges, thereby potentially extending patients' lifespans.

Keywords:
AMLAllogeneic stem cell transplantationCensored quantile regressionSurvival

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