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Extracellular Vesicles Secreted by Cancer-Associated Fibroblasts Drive Non-Invasive Cancer Cell Progression to

Adilson Fonseca Teixeira1,2, Yanhong Wang1, Josephine Iaria1,2

  • 1Department of Surgery (The Royal Melbourne Hospital), The University of Melbourne, Parkville, Victoria, Australia.

Journal of Extracellular Vesicles
|March 17, 2025
PubMed
Summary

Cancer-associated fibroblasts (CAFs) release small extracellular vesicles (sEVs) that promote cancer metastasis by activating TGF-β signaling. Targeting CAF-sEV secretion with DMA inhibits metastasis and tumor self-seeding.

Keywords:
TGF‐βcancer‐associated fibroblastscirculating tumour cellsextracellular vesiclesmetastasistherapytumour microenvironment

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