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Silybin loaded Ag-nanoparticles as a drug delivery system for solid tumor theragnosis: Extraction, radioiodination,
Basma M Essa1, Islam M Abdelmonem2, Mohamed A Amin3
1Department of Radioactive Isotopes and Generator, Hot Laboratories Centre, Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Abstract:
Biocompatible silver nanoparticles (AgNPs) are employed with an active ingredient of milk thistle extract, silybin (SIB), to treat cancers. Strong cytotoxic effects of SIB-AgNPs against two distinct cell lines (MCF-7 and HepG2) are observed on a stable nano-platform that contains spherical nanoparticles within a limited size range. With a high radiochemical purity, radioiodination of SIB-AgNPs was accomplished. The investigation on the biodistribution of [131I]iodo-SIB-AgNPs in mice-bearing tumors showed that SIB-AgNPs prefer localization in tumor tissue. In conclusion, this work strengthens the case for [131I]iodo-SIB-AgNPs as an effective theranostic agent for tumor imaging and treatment.
