Two cases of obsessive-compulsive disorder with depression responsive to trazodone

Two patients with severe obsessive-compulsive disorder with superimposed depression, who had failed to respond to a wide variety of antidepressants, were treated with trazodone hydrochloride. Both seemed to obtain a rapid and impressive improvement in both their depression and obsessive-compulsive disorder while receiving trazodone. One patient subsequently had a monoamine oxidase inhibitor added to his treatment and experienced some additional improvement, but most of his improvement had occurred earlier, while he was receiving trazodone only.