Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menopause01:28

Menopause

111
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
111
Bone Disorders01:29

Bone Disorders

3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
Bone Remodeling01:40

Bone Remodeling

38.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.1K
Oogenesis02:07

Oogenesis

63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

371
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
371
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

286
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
286

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Metabolic bone disorders: what the internist must not overlook].

Innere Medizin (Heidelberg, Germany)·2026
Same author

Sustained Improvement in Renal Function with Palopegteriparatide in Adults with Chronic Hypoparathyroidism: 2-Year Results from the Phase 3 PaTHway-Trial.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Pathophysiology, diagnosis and management of secondary osteoporosis.

Nature reviews. Endocrinology·2026
Same author

<i>Thra</i> knockout protects male mice from hyperthyroidism-driven cortical bone loss by mitigating bone resorption.

JBMR plus·2026
Same author

Predicting bone fragility in perimenopause: Results from the SWAN Study.

The Journal of clinical endocrinology and metabolism·2026
Same author

Therapeutic Management of Glucocorticoid-Induced Osteoporosis with a Focus on Older Adults: A Narrative Review.

Drugs & aging·2025

Related Experiment Video

Updated: May 22, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

426

[Premenopausal osteoporosis].

Elena Tsourdi1,2

  • 1Bereich Endokrinologie/Diabetes/Metabolische Knochenerkrankungen, Medizinische Klinik III und UniversitätsCentrum für Gesundes Altern (UCGA), Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland.

Therapeutische Umschau. Revue Therapeutique
|March 17, 2025
PubMed
Summary

Premenopausal osteoporosis, though uncommon, requires attention. Lifestyle, calcium, vitamin D, and physical activity can improve bone mass, while certain medications may be considered for recurrent fractures.

Keywords:
Premenopausal osteoporosisearly-onset osteoporosisestrogen deficiencygenetic testingosteoporotic fractures

More Related Videos

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

805
A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

15.3K

Related Experiment Videos

Last Updated: May 22, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

426
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

805
A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

15.3K

Area of Science:

  • Endocrinology and Bone Metabolism
  • Women's Health
  • Osteoporosis Research

Background:

  • Premenopausal osteoporosis is underdiagnosed due to its rarity and less defined diagnostic criteria compared to postmenopausal osteoporosis.
  • Fragility fractures and low bone mass are less common but significant indicators in premenopausal women.
  • Lifestyle, diet (calcium, vitamin D), and physical activity significantly impact premenopausal bone health.

Purpose of the Study:

  • To outline diagnostic procedures for premenopausal women presenting with fragility fractures or bone-compromising conditions.
  • To review current understanding of factors influencing premenopausal bone mass.
  • To discuss therapeutic strategies for premenopausal osteoporosis, including lifestyle modifications and pharmacological interventions.

Main Methods:

  • Review of recent studies on lifestyle, dietary habits, and bone mass in premenopausal women.
  • Analysis of diagnostic criteria and procedures for premenopausal osteoporosis.
  • Evaluation of pharmacological interventions like bisphosphonates and teriparatide for managing bone loss.

Main Results:

  • Adequate calcium and vitamin D intake, combined with physical activity, can improve bone mass in idiopathic premenopausal osteoporosis.
  • Secondary causes of osteoporosis must be addressed.
  • Pharmacological interventions may be considered for recurrent fractures or irreversible secondary causes, though fracture endpoints are not yet established.

Conclusions:

  • Early diagnostic procedures are crucial for premenopausal women with risk factors for osteoporosis.
  • Lifestyle modifications and nutritional support are foundational for improving bone health.
  • Pharmacological agents show promise in increasing bone mass, but further research is needed on fracture prevention.