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Verona Integron-Encoded Metallo-β-Lactamase (VIM)-Producing Pseudomonas aeruginosa Pyelonephritis in a Young Adult: A

Gerson De Freitas1

  • 1Internal Medicine, St. Luke's Hospital, Bethlehem, USA.

Cureus
|March 17, 2025
PubMed

Insights

A rare case of community-acquired pyelonephritis caused by Verona integron-encoded metallo-β-lactamase (VIM)-producing Pseudomonas aeruginosa was successfully treated. Ceftazidime-avibactam proved effective against this carbapenem-resistant Pseudomonas aeruginosa (CRPA) infection.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • The rise of carbapenem-resistant Gram-negative bacteria poses a significant global health threat.
  • Pseudomonas aeruginosa is a common opportunistic pathogen, and carbapenem resistance limits treatment options.

Observation:

  • A young female presented with community-acquired pyelonephritis.
  • Urine culture isolated Verona integron-encoded metallo-β-lactamase (VIM)-producing Pseudomonas aeruginosa.

Findings:

  • The patient was successfully treated with ceftazidime-avibactam.
  • This demonstrates the efficacy of ceftazidime-avibactam against VIM-producing P. aeruginosa.

Implications:

  • Highlights the emergence of carbapenem-resistant P. aeruginosa (CRPA) in community settings.
  • Suggests ceftazidime-avibactam as a viable therapeutic option for CRPA infections.
  • Emphasizes the need for surveillance and rapid diagnostics for resistant pathogens.
Keywords:
carbapenem resistancepseudomonas aeruginosapyelonephritisvimvim-pseudomonas

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