Postpolypectomy Syndrome Without the Use of Hot Snare

The mechanism of postpolypectomy syndrome (PPS) has been largely attributed to transmural injury related to electrocoagulation. This syndrome classically presents with fever, leukocytosis, localized peritoneal inflammation, and abdominal pain following colonoscopy with polypectomy, resolving with conservative management. However, this case describes a patient who presented with these symptoms after undergoing resection of 11 polyps via cold snare and biopsy forceps. Histology did not show deep colonic injury from the polypectomy, and no electrocoagulation was used, making this case inconsistent with the accepted explanation of postpolypectomy syndrome.