Kikuchi Disease in a Young Woman With Sickle Cell Disease: A Case Report

Kikuchi-Fujimoto disease (KFD) is a rare, benign, and self-limiting disorder characterized by necrotizing lymphadenitis, primarily affecting young adults and adolescents. Its etiology and pathogenesis remain unclear and complex. Common presentations include constitutional symptoms such as lymphadenopathy and fever. This study reports the case of a 15-year-old girl who presented with a fever of unknown origin and was found to have lymphadenopathy, which was associated with sickle cell disease (SCD). The diagnosis was confirmed through the pathological features of lymph node biopsy, with the patient successfully treated with steroids and hydroxychloroquine. She remained stable on follow-up, with no recurrence of fever or lymphadenopathy.