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Updated: May 22, 2025

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Published on: January 27, 2018
Non-classical Congenital Adrenal Hyperplasia Presenting With Severe Androgenic Alopecia: A Case Report
Khalid Al Hawsawi1, Hamazah Qul2, Ameera A Alkhamesi3
1Dermatology, King Abdulaziz Hospital, Makkah, SAU.
Abstract:
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder with cortisol synthesis impairment, commonly due to CYP21A2 gene mutations. Non-classical CAH (NCCAH) presents with hyperandrogenic symptoms such as acne, hirsutism, severe androgenic alopecia, and infertility. We report a 37-year-old female who presented with severe acne, progressive hair loss, and primary infertility despite regular menstrual cycles. Laboratory tests were normal except for elevated 17α-hydroxyprogesterone (17-OHP). Prednisolone was initiated to manage symptoms and address fertility.
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