Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral chemoreceptors and exercise hyperpnea.

B J Whipp, J A Davis

    Medicine and Science in Sports
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Carotid bodies are key for breathing control during exercise. They respond to signals like CO2 and pH changes, especially during intense activity, to regulate ventilation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Recomendações sobre o uso dos testes de exercício na prática clínica.

    Revista portuguesa de pneumologia·2015
    Same author

    The physiological basis of the 'anaerobic threshold' and implications for clinical cardiopulmonary exercise testing.

    Anaesthesia·2011
    Same author

    Effect of recovery duration from prior exhaustive exercise on the parameters of the power-duration relationship.

    Journal of applied physiology (Bethesda, Md. : 1985)·2010
    Same author

    Quantifying intervention-related improvements in exercise tolerance.

    The European respiratory journal·2009
    Same author

    Thoracic sympathectomy and cardiopulmonary responses to exercise.

    European journal of applied physiology·2008
    Same author

    Effects of prior very-heavy intensity exercise on indices of aerobic function and high-intensity exercise tolerance.

    Journal of applied physiology (Bethesda, Md. : 1985)·2007

    Area of Science:

    • Physiology
    • Exercise Physiology
    • Respiratory Control

    Background:

    • Carotid bodies are the primary peripheral chemoreceptors for ventilatory control during human exercise.
    • Stimulation mechanisms are not fully understood, but effects on pulmonary ventilation (VE) are known.
    • Known stimuli include hypercapnia, hypoxia, acidosis, blood pressure, temperature, and catecholamines.

    Purpose of the Study:

    • Investigate the role of carotid bodies in ventilatory control during exercise.
    • Explore potential mechanisms for CO2 signal transmission to the respiratory center.
    • Clarify the carotid body's contribution to hyperpnea at different exercise intensities.

    Main Methods:

    • Review of existing literature on carotid body function and exercise physiology.

    Related Experiment Videos

  • Analysis of physiological responses to varying exercise intensities.
  • Discussion of proposed theories for CO2 signal transduction.

    • Main Results:

    • Carotid bodies mediate ventilatory control during exercise, with intensity-dependent roles.
    • During heavy exercise, carotid bodies exclusively mediate ventilatory compensation for acidosis.
    • During moderate exercise, arterial PCO2 remains stable, posing a question about CO2 signal transmission.

    Conclusions:

    • Carotid bodies are essential for exercise-induced hyperpnea and acidosis compensation.
    • Two theories propose how CO2 signals may stimulate carotid bodies during exercise: respiratory oscillations or intracellular/extracellular pH disequilibrium.