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Autoimmune Pancreatitis Presenting as Multifocal Masses: A Rare Case Report
Aqsa Khan1, Rizwan Mushtaq2, Essam Rashad1
1Internal Medicine, Parkview Health, Fort Wayne, USA.
Cureus
|March 17, 2025
Summary
Autoimmune pancreatitis (AIP), a rare condition mimicking cancer, was diagnosed in a patient with enlarged lymph nodes. Corticosteroid treatment effectively resolved symptoms, underscoring AIP
Area of Science:
- Gastroenterology and Immunology
Background:
- Autoimmune pancreatitis (AIP) presents diagnostic challenges due to its resemblance to pancreatic cancer.
- AIP has two subtypes: Type 1, associated with IgG4-related disease, and Type 2, pancreas-confined.
Observation:
- A 64-year-old woman presented with submandibular and cervical lymphadenopathy.
- Imaging revealed FDG-avid lymph nodes and pancreatic abnormalities, initially suspicious for malignancy.
- Biopsy confirmed Type 1 AIP and IgG4-related sialadenitis.
Findings:
- Diagnosis of Type 1 autoimmune pancreatitis (AIP) and IgG4-related sialadenitis.
- Successful treatment with corticosteroids led to symptom resolution and improved imaging.
- Demonstrates atypical presentation of AIP.
Implications:
- Highlights the importance of considering AIP in differential diagnoses, even with atypical presentations.
- Emphasizes the efficacy of corticosteroid therapy for IgG4-related conditions.
- AIP diagnosis requires careful evaluation to avoid misdiagnosis as pancreatic cancer.
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