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Cyclic neutropenia: a case report and literature review

Jun-Li Li1, Jing-Jing Zhao1, Rui-Jun Li1

  • 1Department of Pediatrics, Inner Mongolia Autonomous Region Maternal and Child Health Hospital Hohhot 010000, Inner Mongolia, China.

American Journal of Translational Research
|March 17, 2025
PubMed

Insights

Cyclic neutropenia (CyN) is a rare disorder characterized by periodic low neutrophil counts. Genetic testing, particularly for ELANE mutations, is crucial for diagnosing CyN in children with recurrent infections.

Area of Science:

  • Hematology
  • Genetics
  • Pediatrics

Background:

  • Cyclic neutropenia (CyN) is a rare hematologic disorder.
  • It is characterized by recurrent, predictable drops in neutrophil counts.
  • This leads to increased susceptibility to infections.

Keywords:
Congenital neutropeniaELANEG-CSFcyclic neutropeniasevere congenital neutropenia

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