Coagulation indices for predicting hypertensive pregnancy disorders.

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Perinatal Medicine

Background:

• Hypertensive disorders in pregnancy (HDP) pose significant risks to maternal and fetal well-being.
• Early detection and monitoring of HDP are crucial for improving outcomes.
• Coagulation function plays a role in the pathophysiology of HDP.

Purpose of the Study:

• To investigate the correlation between coagulation function indicators during mid-to-late gestation and the development/severity of HDP.
• To evaluate the predictive value of these indicators for HDP.
• To inform strategies for early HDP detection and management.

Main Methods:

• Retrospective analysis of 300 pregnant women (182 with HDP, 118 controls) from October 2020 to October 2023.
• Collection of clinical data including age, gestational age, parity.
• Assessment of coagulation function indicators via blood tests.

Main Results:

• Platelet count (PLT), thrombin time (TT), and fibrinogen (Fib) were independent prognostic factors for HDP.
• Pregnant women with HDP exhibited higher rates of adverse outcomes including preterm delivery, postpartum hemorrhage, and fetal growth restriction.

Conclusions:

• Prothrombin Time (PT), activated partial thromboplastin time (APTT), TT, Fib, and international normalized ratio are indicative of HDP severity.
• Coagulation parameters offer valuable insights into HDP status and prognosis.