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Published on: March 19, 2018
Effectiveness of Platelet-Rich Plasma in Treating Rotator Cuff Tendinopathy: A Systematic Review and Meta-Analysis
Mainak Roy1, Mulagondla Harshavardhan Reddy2, Deepanjan Das2
1Department of Orthopaedics, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Introduction:
Rotator cuff tendinopathy often causes significant shoulder pain and limits function. Traditional treatments, such as physical therapy and corticosteroid injections, provide inconsistent relief. Platelet-rich plasma (PRP) has emerged as a promising regenerative therapy for pain relief and tendon healing. This systematic review and meta-analysis evaluated PRP's effectiveness compared to placebo or other treatments.
Materials And Methods:
A thorough search of PubMed, Embase, and Cochrane Library focused on randomized controlled trials (RCTs) using PRP as a primary intervention for rotator cuff tendinopathy. Eligible studies included pain reduction, functional improvement, and retear rates as outcomes. Data were extracted and analyzed using standardized methods.
Results:
Thirty RCTs with around 2,500 participants were included in the study. PRP significantly reduced pain and improved function in the short term compared to placebo and corticosteroids. However, long-term benefits (beyond 12 months) were limited, with retear rates and function similar to control groups.
Conclusion:
PRP provides significant short-term pain relief and functional improvement in rotator cuff tendinopathy but does not demonstrate superior long-term benefits over placebo or corticosteroids.
