Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peri-operative Safety and Complications of Central Venous Access Device in Paediatric-Haemato-Oncology Patients: A Single-Centre Experience of 180 Procedures with Special Focus on Chemoport Insertion.

Indian journal of surgical oncology·2026
Same author

Towards a bioengineered airway: advances in tracheal tissue engineering and biofabrication.

Frontiers in cell and developmental biology·2026
Same author

Degrading Resistance on Command: LAMP-D Reframes Targeted Protein Degradation as a Photochemical Problem.

ChemMedChem·2026
Same author

Robotic intersphincteric resection with partial excision of external sphincter (Type IV ISR) using Hugoâ„¢ RAS system: A video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same author

A comprehensive review of microfluidic-based organ-on-chip technology in the application of preclinical drug discovery studies.

Biochimica et biophysica acta. Reviews on cancer·2026
Same author

Emerging Utility of Artificial Intelligence Driven Medical Robots in Health Care: A Review.

Current pharmaceutical design·2026

Related Experiment Video

Updated: May 22, 2025

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts
08:17

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts

Published on: April 14, 2023

811

Decellularization techniques: unveiling the blueprint for tracheal tissue engineering.

Keisha T Gomes1, Palla Ranga Prasad1, Jagnoor Singh Sandhu2,3

  • 1Department of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.

Frontiers in Bioengineering and Biotechnology
|March 17, 2025
PubMed
Summary
This summary is machine-generated.

Tissue engineering offers a promising solution for trachea repair by using decellularized scaffolds. These scaffolds, when repopulated with cells, can restore trachea structure and function, addressing limitations in current treatments.

Keywords:
decellularizationrecellularizationscaffoldstracheatransplantation

More Related Videos

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
11:01

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Published on: April 6, 2022

2.5K
Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
09:57

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

Published on: April 1, 2019

7.2K

Related Experiment Videos

Last Updated: May 22, 2025

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts
08:17

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts

Published on: April 14, 2023

811
Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
11:01

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Published on: April 6, 2022

2.5K
Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
09:57

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

Published on: April 1, 2019

7.2K

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Tracheal damage from diseases or trauma lacks permanent solutions, especially for long-segment defects.
  • Current treatments for tracheal defects are insufficient, necessitating novel approaches.
  • Tissue engineering presents a viable strategy to address these unmet clinical needs.

Purpose of the Study:

  • To review advancements in tracheal decellularization techniques.
  • To explore optimized recellularization strategies for engineered tracheal grafts.
  • To examine critical factors for successful transplantation of tissue-engineered tracheas.

Main Methods:

  • Review of decellularization processes for native tracheal tissue.
  • Analysis of various stem cell and tissue-specific cell types for recellularization.
  • Evaluation of key parameters including mechanical properties, revascularization, and immunogenicity.

Main Results:

  • Decellularized scaffolds preserve native extracellular matrix, reducing immunogenicity.
  • Scaffolds retain biomechanical and proangiogenic properties essential for regeneration.
  • Optimized recellularization can restore scaffold structure and function.

Conclusions:

  • Decellularization followed by recellularization is a promising approach for trachea regeneration.
  • Careful selection of cells and optimization of graft properties are crucial for clinical success.
  • Tissue-engineered tracheal grafts hold potential to overcome limitations of current treatments.