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Association between high-sensitivity troponin T levels below the ninety-ninth percentile and diabetic kidney disease:

Xiao-Yan Luo1, Li-Hua Huang2, Kun-Peng Kang3

  • 1Department of Interventional Radiology, The Second Affiliated Hospital of Gannan Medical University, Ganzhou 341600, Jiangxi Province, China.

World Journal of Diabetes
|March 17, 2025
PubMed

Insights

Detectable high-sensitivity troponin T (hs-TnT) levels below the 99th percentile are linked to diabetic kidney disease (DKD) in type 2 diabetes patients. This finding highlights a potential risk marker for DKD in individuals with diabetes.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Myocardial injury identification traditionally uses high-sensitivity troponin T (hs-TnT) above the 99th percentile.
  • Patients with hs-TnT below this threshold are a poorly understood group with varied risk profiles.

Purpose of the Study:

  • To examine the association between hs-TnT levels below the 99th percentile and diabetic kidney disease (DKD).
  • To investigate this relationship in patients diagnosed with diabetes mellitus.

Main Methods:

  • Analysis of National Health and Nutrition Examination Survey data (1999-2004) from type 2 diabetes patients.
  • DKD defined by impaired glomerular filtration rate and/or proteinuria.
  • Weighted multivariable logistic regression and restricted cubic spline analyses were used.

Main Results:

  • The study included 2505 participants; 32.34% had DKD.
  • Higher hs-TnT tertiles (5.94-9.79 ng/L and 9.80-21.88 ng/L) showed increased odds of DKD compared to the lowest tertile.
  • A significant trend (P=0.022) and linear association between hs-TnT and DKD were observed.

Conclusions:

  • Detectable hs-TnT levels below the 99th percentile are associated with DKD in type 2 diabetes patients.
  • These findings suggest hs-TnT may serve as a risk indicator for DKD in this population.
Abstract

Keywords:
99th percentileDiabetic kidney diseaseDiabetic nephropathiesHigh-sensitivity troponin TNational Health and Nutrition Examination Survey

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