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Metastructure and strain-defect engineered Cu-doped TiO coating to enhance antibacterial sonodynamic therapy
Songsong Wang1,2, Ji Tan1, Haifeng Zhang1
1State Key Laboratory of Advanced Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Bioactive Materials
|March 17, 2025
Summary
This study developed a novel ultrasound-triggered coating for implants, effectively eliminating bacterial infections and improving bone healing. The innovative metastructure coating enhances sonodynamic therapy (SDT) for better implant outcomes.
Area of Science:
- Biomaterials Engineering
- Nanotechnology
- Infectious Diseases
Background:
- Implant-associated infections are a major cause of implant failure.
- Current treatments for implant infections are often insufficient.
- Developing effective ultrasound-triggered coatings for implants is challenging.
Purpose of the Study:
- To create an efficient ultrasound-triggered coating for titanium implants.
- To enhance sonodynamic therapy (SDT) for treating implant-associated infections.
- To improve implant osseointegration after infection clearance.
Main Methods:
- Fabrication of a Cu-doped defective titanium oxide (Cu-TiO2) acoustic metastructure coating on titanium implants.
- Utilizing lattice strain and Cu atom redistribution to optimize energy structure for enhanced sonocatalysis.
- Investigating the ultrasound absorption and reactive oxygen species generation of the coating.
- Evaluating the efficacy of the coating against Staphylococcus aureus and Escherichia coli infections in vitro and in vivo.
Main Results:
- The Cu-TiO2 metastructure coating demonstrated enhanced sonocatalytic generation of reactive oxygen species.
- Ultrasound absorption by the coating was significantly improved, boosting sonocatalytic activity.
- The coating efficiently eliminated Staphylococcus aureus and Escherichia coli infections within 10 minutes under ultrasonic irradiation.
- Significant improvement in the osteogenic property of the implant was observed in vivo after infection clearance.
Conclusions:
- The developed Cu-TiO2 acoustic metastructure coating is effective for sonodynamic therapy against implant-associated infections.
- Strain-defect engineering and metastructure design can significantly enhance SDT performance.
- This approach offers a promising strategy for developing advanced biosurfaces for improved implant outcomes.
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