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Iron malabsorption in giardiasis.

B De Vizia, V Poggi, P Vajro

    The Journal of Pediatrics
    |July 1, 1985
    PubMed
    Summary
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    Giardiasis commonly causes iron deficiency in children, impacting iron absorption. Treatment with metronidazole improved iron absorption in most children, suggesting malabsorption is a complication of this parasitic infection.

    Area of Science:

    • Pediatric Gastroenterology
    • Infectious Diseases
    • Nutritional Science

    Background:

    • Giardiasis is a common intestinal infection.
    • Iron deficiency is prevalent in children.
    • The link between giardiasis and iron malabsorption requires further investigation.

    Purpose of the Study:

    • To investigate iron absorption in children with giardiasis.
    • To assess the impact of giardiasis on iron status.
    • To evaluate the efficacy of metronidazole in correcting iron malabsorption.

    Main Methods:

    • Oral iron load tests were used to assess iron absorption.
    • Xylose absorption tests were conducted.
    • Jejunal biopsy morphologic studies were performed.

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  • Metronidazole treatment was administered.

    • Main Results:

    • Eight of ten children with giardiasis had iron deficiency.
    • Iron absorption was subnormal in iron-deficient patients.
    • Metronidazole improved iron absorption in seven patients.
    • Xylose absorption normalized after treatment in most patients.

    Conclusions:

    • Malabsorption of iron is a complication of giardiasis in children.
    • Metronidazole treatment can improve iron absorption.
    • IgA deficiency may be associated with persistent malabsorption.