A Study to Compare the Relationship Between Tissue Eosinophilia and Radiological Findings in Nasal Polyposis

Nasal polyps are benign inflammatory growth of sinonasal mucosa, often associated with chronic rhinosinusitis. This condition prevalent among adults, significantly impacts the quality of life. Eosinophil plays a crucial role in the pathogenesis of nasal polyposis. Hence, this study was carried out to compare the relationship between tissue eosinophilia and radiological findings in nasal polyposis. This observational study was conducted at a tertiary care centre, involving 30 patients with nasal polyposis underwent endoscopic sinus surgery. All patients underwent pre operative CT scan and Lund MacKay score were calculated. Excised polyp tissues were examined, and eosinophil count was calculated per high power field (400 X). Eosinophil count was categorized as low (≤ 10 E/HPF) and high (> 10 E/HPF). The study population had a mean age of 41.65 ± 11.43 years, with a male predominance (80%). Hypertension was the most common comorbidity (26.67%). The mean Lund MacKay score was 18.03 ± 4.3 with the majority of patients (60%) had Lund-Mackay scores between 17-24, indicating significant sinus involvement. Patients with higher eosinophil counts (> 10 E/HPF) showed more severe disease, reflected by higher Lund-Mackay scores (p < 0.0001). A moderate positive correlation (r = 0.005) was observed between tissue eosinophil count and Lund-Mackay scores. This study found moderate positive correlation between the Lund Mackay score and tissue eosinophil count. The correlation between tissue eosinophil count and disease severity underscores its potential as a prognostic marker in nasal polyposis.