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Related Experiment Video

Updated: May 22, 2025

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

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WAO - ARIA consensus on chronic cough: Executive summary.

Philip W Rouadi¹, Samar A Idriss¹, Jean Bousquet^2,3,4

¹Department of Otolaryngology, Dar Al Shifa Hospital, Hawally, Kuwait.

The World Allergy Organization Journal

|March 17, 2025

Summary

Chronic cough is a complex condition impacting quality of life. This summary reviews its pathophysiology, phenotypes, and management for clinicians, aiming to improve patient outcomes through increased awareness.

Keywords:

Chronic cough Gastroesophageal reflux disease Hypersensitive cough reflex Lower airway disease Multifactorial chronic cough Neuromodulators Primary care physician Refractory chronic cough Unexplained chronic cough Upper airway disease

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Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Area of Science:

Pulmonology
Neurology
Pharmacology

Background:

Chronic cough significantly impacts patient quality of life.
Mechanistic pathways in complex cough phenotypes remain unclear.
Hypersensitive cough reflex and specific receptors (transient receptor potential channels, P2X receptors) are implicated in cough pathways.

Purpose of the Study:

To provide clinicians with a succinct summary of chronic cough pathophysiology, clinical phenotypes, and management.
To serve as a primer for primary care physicians and cough specialty care providers.
To increase awareness of chronic cough to improve patient management outcomes.

Main Methods:

Review of updated experimental and clinical data on chronic cough.
Inclusion of a multidisciplinary care pathway approach.
Synthesis of information for clinical application.

Main Results:

Elucidation of mechanistic pathways in chronic cough is ongoing.
Evidence points to a hypersensitive cough reflex.
Transient receptor potential channels and P2X receptors are key neuronal players.

Conclusions:

Increased awareness among primary care physicians is crucial for better chronic cough management.
Understanding pathophysiology and phenotypes aids in effective treatment strategies.
A multidisciplinary approach is recommended for managing chronic cough.