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Updated: Aug 7, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
General mechanisms of antimicrobial resistance
1Department of Biochemistry, University of Wisconsin-Madison 53706.
Abstract:
Bacteria can become resistant to antimicrobial agents by two routes, either by mutation or by the inheritance of new genetic information in the form of resistance plasmids. The mechanisms by which bacteria express resistance are manyfold, and five different biochemical mechanisms have been demonstrated in clinical isolates. The most important mechanisms are alteration of the drug target site, interference with the transport of the antimicrobial agent into the cell, and detoxification (inactivation) of the drug in the immediate environment of the cell.
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