Related Experiment Video

Updated: May 22, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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Circular RNA in Pancreatic Cancer: Biogenesis, Mechanism, Function and Clinical Application

Hang Chen1, Xianxing Wang1, Shan Liu2

  • 1Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, Chongqing University, Chongqing, 401147, China.

International Journal of Medical Sciences
|March 17, 2025
PubMed

Insights

Circular RNAs (circRNAs) play key roles in pancreatic cancer (PC) development. This review details their biogenesis, functions, and potential as biomarkers and therapeutic targets for PC.

Area of Science:

  • Molecular Biology
  • Genomics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are highly conserved, covalently closed RNA molecules found in eukaryotes.
  • circRNAs exhibit tissue- and cell-specific expression, indicating potential as diagnostic and prognostic biomarkers.
  • They play critical roles in pancreatic cancer (PC) progression through diverse molecular mechanisms.

Purpose of the Study:

  • To systematically review the biogenesis, function, molecular mechanisms, and clinical applications of circRNAs in pancreatic cancer.
  • To highlight the potential of circRNAs as biomarkers for PC diagnosis and prognosis.
  • To discuss circRNAs as therapeutic targets for pancreatic cancer.

Main Methods:

  • Literature review of recent studies on circRNAs in pancreatic cancer.
  • Systematic summary of circRNA biogenesis and functional mechanisms.
  • Analysis of circRNAs' roles in PC occurrence and progression.

Main Results:

  • circRNAs function as miRNA sponges, RBP sponges, transcriptional regulators, molecular scaffolds, and translation templates.
  • circRNAs are implicated in the occurrence and progression of pancreatic cancer.
  • circRNAs show promise as biomarkers for PC diagnosis and prognosis.

Conclusions:

  • Understanding circRNA biogenesis and function is crucial for advancing pancreatic cancer research.
  • Addressing technical challenges in circRNA detection will facilitate clinical applications.
  • circRNAs represent promising biomarkers and therapeutic targets for pancreatic cancer.
Keywords:
biomarkercircRNAmiRNApancreatic cancertherapeutic target

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