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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Updated: May 22, 2025

A Contrast of Three Inoculation Techniques used to Determine the Race of Unknown Fusarium oxysporum f.sp. niveum Isolates

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Bloodstream Infection Caused by Mucor velutinosus.

Lori D Racsa¹, Brian Willis¹, Shawn R Lockhart²

¹Department of Pathology and Laboratory Medicine, Emory University, School of Medicine.

Infectious Diseases in Clinical Practice (Baltimore, Md.)

|March 17, 2025

Summary

A rare fungal infection caused by Mucor velutinosus occurred in an immunocompromised patient undergoing chemotherapy for diffuse large B-cell lymphoma. This case highlights the importance of rapid identification of emerging fungal pathogens in clinical settings.

Keywords:

Mucor Mucorales blood mold

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Area of Science:

Medical Mycology
Clinical Microbiology
Infectious Diseases

Background:

Neutropenic fever is a common complication in patients undergoing chemotherapy for hematologic malignancies like diffuse large B-cell lymphoma.
Fungal infections, particularly those caused by molds, can be life-threatening in immunocompromised individuals.
Accurate and timely identification of fungal pathogens is crucial for effective treatment.

Purpose of the Study:

To report a case of fungemia caused by Mucor velutinosus in a patient with diffuse large B-cell lymphoma.
To emphasize the diagnostic challenges and clinical significance of identifying rare fungal species in immunocompromised hosts.

Main Methods:

Blood cultures were drawn from a patient presenting with neutropenic fever.
Gram stain and chocolate agar cultures were used for initial fungal detection and morphology assessment.
Tease preparation and sequencing were performed for definitive species identification.

Main Results:

Blood cultures flagged positive after 48 hours, revealing thin, septate hyphae on Gram stain.
Culture plates showed gray fluffy mold consistent with Mucorales.
Sequencing identified the causative agent as Mucor velutinosus.

Conclusions:

Mucor velutinosus can cause invasive fungal infections, including fungemia, in immunocompromised patients.
Early detection and accurate identification of Mucor velutinosus are essential for appropriate antifungal therapy and improved patient outcomes.
This case underscores the need for vigilance in diagnosing rare fungal infections in susceptible populations.