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Engineered Probiotic-Based Biomaterials for Inflammatory Bowel Disease Treatment
Guangze Sang1, Bingkai Wang1, Yujie Xie2
1Department of Inorganic Chemistry, School of Pharmacy, Naval Medical University, Shanghai, 200433, P. R. China.
Theranostics
|March 17, 2025
Summary
Engineered probiotics offer a promising, targeted approach to managing inflammatory bowel disease (IBD) with fewer side effects than traditional therapies. This review explores advancements in probiotic-based treatments for IBD.
Area of Science:
- Gastroenterology
- Biotechnology
- Microbiology
Background:
- Inflammatory bowel disease (IBD) is a chronic, relapsing immune-mediated intestinal inflammation.
- Current treatments for IBD, including small molecule drugs and monoclonal antibodies, present challenges in efficacy and side effect profiles.
- Probiotics are emerging as a viable therapeutic alternative for IBD management.
Purpose of the Study:
- To review recent advancements in engineering probiotic-based materials for inflammatory bowel disease (IBD) treatment.
- To elucidate the therapeutic mechanisms of probiotics within the intestinal environment.
- To discuss strategies for enhancing probiotic efficacy in IBD management.
Main Methods:
- Review of current literature on probiotic engineering and IBD.
- Analysis of probiotic therapeutic mechanisms and modification techniques.
- Exploration of genetic modifications and formulation strategies to improve probiotic efficacy.
Main Results:
- Probiotics act as "living" therapeutic agents with targeted action and minimal side effects.
- Engineering strategies, including genetic modification and formulation improvements, can significantly enhance probiotic efficacy for IBD.
- Probiotic-based therapies demonstrate potential for flexible biological modifications.
Conclusions:
- Engineered probiotics represent a promising therapeutic strategy for inflammatory bowel disease (IBD).
- Further research into challenges, practical applications, and clinical implications is warranted.
- Probiotic-based therapies offer a potentially safer and more effective alternative for IBD treatment.
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