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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

280
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
280

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Updated: May 22, 2025

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IgG-Associated Hypocomplementemia in Neonatal Lupus: A Retrospective Multicenter Study.

Wenqiang Sun1, Yihui Li1, Xinyun Jin1

  • 1Department of Neonatology, Children's Hospital of Soochow University, Suzhou, People's Republic of China.

Journal of Inflammation Research
|March 17, 2025
PubMed
Summary

Hypocomplementemia in neonatal lupus erythematosus (NLE) is linked to maternal factors like allergies and double antibody positivity. These infants face a more severe disease course with increased risks of allergies and developmental delays.

Keywords:
hypocomplementemiaimmunoglobulin Glupus erythematosusneonateprognosisrisk factors

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Area of Science:

  • Pediatrics
  • Immunology
  • Rheumatology

Background:

  • Hypocomplementemia, low C3 or C4 levels, indicates poor prognosis in autoimmune diseases.
  • Neonatal lupus erythematosus (NLE) is a condition where maternal autoantibodies cross the placenta, affecting the neonate.
  • The association between hypocomplementemia and clinical outcomes in NLE requires further investigation.

Purpose of the Study:

  • To explore the clinical features of NLE patients with hypocomplementemia.
  • To identify risk factors associated with hypocomplementemia in NLE.
  • To compare the outcomes of NLE patients with and without hypocomplementemia.

Main Methods:

  • Retrospective study of 91 NLE patients across four tertiary hospitals (2011-2023).
  • Patients classified into hypocomplementemic and non-hypocomplementemic groups based on C3/C4 levels.
  • Univariate/multifactorial analyses for risk factors; comparison of organ involvement and follow-up outcomes.

Main Results:

  • 39.56% of NLE patients had hypocomplementemia.
  • Risk factors included maternal allergic diseases, double antibody (anti-SSA/SSB) positivity, and higher serum IgG levels.
  • Hypocomplementemic NLE patients showed higher rates of thrombocytopenia, hypoproteinemia, gastrointestinal issues, and later-life allergies/developmental delays.

Conclusions:

  • Maternal allergic diseases, double antibody positivity, and elevated IgG are associated with hypocomplementemia in NLE.
  • Hypocomplementemia in NLE patients correlates with a more severe disease course and poorer long-term outcomes.
  • Early identification of hypocomplementemia is crucial for managing NLE and predicting potential complications.