Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cefoxitin and cephamycins: microbiological studies.

E O Stapley1, J Birnbaum, A K Miller

  • 1Merck Institute for Therapeutic Research, Rahway, New Jersey 07065.

Reviews of Infectious Diseases
|January 1, 1979
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shear-enhanced dynamic permeability development of magma vesiculating in cylindrical conduits.

Scientific reports·2026
Same author

Data Linkages for Wildfire Exposures and Human Health Studies: A Scoping Review.

GeoHealth·2024
Same author

[Hymenoptera venom allergy: Management of venom extracts shortage or sanitary crisis (Covid-19 pandemic). Stinging Insects Task Force recommendations].

Revue francaise d'allergologie (2009)·2021
Same author

Epidural needle insertion : A large registry analysis.

Der Anaesthesist·2018
Same author

Retrospective study of hypersensitivity reactions to chemotherapeutic agents in a thoracic oncology service.

Journal of clinical pharmacy and therapeutics·2017
Same author

Transient severe tricuspid regurgitation after transplantation of an extremely oversized donor heart in a child-Does size matter? A case report.

Pediatric transplantation·2016

Cefoxitin, a semisynthetic cephamycin antibiotic, shows high resistance to beta-lactamases and broad-spectrum activity, including against anaerobic pathogens like Bacteroides fragilis. Its effectiveness in experimental infections suggests it is a valuable agent for treating bacterial infections.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Cephamycins are beta-lactam antibiotics produced by actinomycetes, structurally related to cephalosporins.
  • A key feature is the 7-alpha-methoxyl group, providing resistance to beta-lactamases.

Purpose of the Study:

  • To evaluate the properties and therapeutic potential of cefoxitin, the first semisynthetic cephamycin.
  • To assess its spectrum of activity and effectiveness against various bacterial pathogens.

Main Methods:

  • Characterization of cefoxitin's chemical structure and resistance mechanisms.
  • Evaluation of its antimicrobial spectrum against Gram-negative and anaerobic bacteria.
  • Assessment of therapeutic efficacy in experimental mouse infection models.

Related Experiment Videos

Main Results:

  • Cefoxitin exhibits high resistance to most beta-lactamases due to its 7-alpha-methoxyl group.
  • It possesses excellent metabolic stability and is bactericidal with minimal inoculum effect.
  • Demonstrates broad-spectrum activity against cephalothin-resistant Gram-negative bacteria, including Serratia and indole-positive Proteus.
  • Effective against anaerobic pathogens, notably Bacteroides fragilis, unlike many cephalosporins.

Conclusions:

  • Cefoxitin is a highly effective semisynthetic cephamycin with significant advantages over traditional cephalosporins.
  • Its broad spectrum, beta-lactamase resistance, and therapeutic efficacy make it a valuable option for treating bacterial infections.