Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pedigree Analysis

Pedigree Analysis

Incomplete Dominance

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.

Chi-square Analysis

Chi-square Analysis

The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...

Hardy-Weinberg Principle

Hardy-Weinberg Principle

Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.

Genetic Lingo

Genetic Lingo

Law of Segregation

Law of Segregation

When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Overdominance for fitness: a genomic comparison between empirical and simulated data with Drosophila melanogaster.

Genetics·2026

Same author

Artificial intelligence for single-omics in ovarian cancer: a methodological review.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026

Same author

SUROVA study: global real-world treatment strategies and mortality risk prediction in advanced ovarian cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2025

Same author

Inbreeding load in finite populations from dominant and overdominant mutations.

Proceedings. Biological sciences·2025

Same author

Accounting for population structure and data quality in demographic inference with linkage disequilibrium methods.

Nature communications·2025

Same author

An international worldwide retrospective cohort observational study comparing primary cytoreductive surgery with neoadjuvant chemotherapy and interval cytoreductive surgery in patients with carcinoma of the ovary, fallopian tubes, and peritoneum (SUROVA trial).

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2025

Search research articles

Related Experiment Video

Updated: May 22, 2025

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Estimation of Inbreeding Depression From Overdominant Loci Using Molecular Markers.

Inés González-Castellano^1,2, Pilar Ordás¹, Armando Caballero¹

¹Centro de Investigación Mariña, Universidade de Vigo Vigo Spain.

Evolutionary Applications

|March 17, 2025

Summary

Inbreeding depression impacts individual fitness due to homozygous expression of hidden alleles. This study shows runs of homozygosity (ROH) provide robust estimates of inbreeding depression, even with overdominant gene action.

Keywords:

Coancestry deleterious recessive mutations genetic drift identity by descent inbreeding load runs of homozygosity

More Related Videos

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi

Published on: October 5, 2018

Related Experiment Videos

Last Updated: May 22, 2025

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi

Induction and Evaluation of Inbreeding Crosses Using the Ant, Vollenhovia Emeryi

Published on: October 5, 2018

Area of Science:

Population genetics
Conservation genetics
Quantitative genetics

Background:

Inbreeding depression reduces individual fitness by exposing deleterious alleles in homozygous states.
The coefficient of inbreeding (F) quantifies inbreeding depression, estimated via pedigrees or molecular markers like SNPs.
Previous studies assumed inbreeding depression solely results from recessive mutations.

Purpose of the Study:

To assess the impact of overdominance on inbreeding depression estimation.
To compare the accuracy of different inbreeding coefficient (F) measures under overdominance.
To identify robust methods for estimating inbreeding depression in the presence of heterozygote advantage.

Main Methods:

Computer simulations were used to model inbreeding depression.
Evaluated various estimators of the inbreeding coefficient (F) based on molecular markers.
Assessed the influence of overdominant gene action on estimator accuracy.

Main Results:

Estimators based on runs of homozygosity (ROH) proved most robust under overdominance.
SNP-by-SNP homozygosity measures showed potential for bias, influenced by allele frequency handling.
Estimators using the correlation between uniting gametes were more reliable among SNP-by-SNP methods.

Conclusions:

Runs of homozygosity (ROH) offer reliable inbreeding depression estimates, accommodating overdominant loci.
Careful consideration of allele frequencies is crucial when using individual SNP homozygosity measures.
The correlation between uniting gametes provides a more dependable SNP-based approach for inbreeding depression estimation.