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Metal-Organic Frameworks-Based Microrockets for Controlled and Sustained Drug Release.

Zixi Wan1,2, Casper H Y Chung1, Chi Ming Laurence Lau3

  • 1Department of Mechanical and Aerospace Engineering, The Hong Kong University of Science and Technology, Hong Kong, SAR, China.

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New microrockets offer targeted gastritis treatment. These zinc-powered, pH-sensitive devices deliver drugs effectively, overcoming challenges with current therapies and improving patient outcomes.

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controlled and sustained releasedrug deliverymetal−organic frameworks (MOFs)microrocketspH-response

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Gastroenterology

Background:

  • Gastritis poses risks like ulcers and cancer, often linked to stress and diet.
  • Current gastritis treatments struggle with patient adherence and antibiotic resistance.
  • Targeted drug delivery systems are needed to improve treatment efficacy.

Purpose of the Study:

  • To engineer novel metal-organic framework (MOF)-based microrockets for targeted gastritis treatment.
  • To develop a self-propelling, pH-sensitive drug delivery system for the gastric environment.
  • To assess the in vivo efficacy and drug retention of the engineered microrockets.

Main Methods:

  • Fabrication of MOF-based microrockets with a zinc-powered engine and pH-sensitive coating.
  • Utilizing bubble propulsion for self-propulsion into gastric mucus.
  • Incorporating a poly(3,4-ethylenedioxythiophene) shell for acid protection and sustained release at neutral pH.
  • Conducting in vivo studies to evaluate drug retention and therapeutic effects.

Main Results:

  • Microrockets demonstrated self-propulsion and mucus penetration capabilities.
  • The pH-sensitive coating ensured MOF protection in acidic conditions and sustained drug release.
  • In vivo studies confirmed prolonged drug retention for up to 48 hours.
  • The system showed potential for active and controlled drug delivery in acidic environments.

Conclusions:

  • Engineered MOF-based microrockets provide a promising solution for targeted gastritis treatment.
  • The biocompatible design offers sustained drug release and improved patient adherence.
  • This technology has potential for broad applications in active and controlled drug delivery systems.