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"Vitamin D Insufficiency in the Cleft Population of the Sub-Himalayan Region"

Madhubari Vathulya1, Neetu Singh2, Manisha Naithani3

  • 1Department of Burns and Plastic Surgery, AIIMS Rishikesh, Rishikesh, Uttarakhand, India.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|March 17, 2025
PubMed

Insights

Children with clefts in the Sub-Himalayan region have significantly lower vitamin D levels than healthy children. This vitamin D deficiency may impact their growth and surgical recovery.

Area of Science:

  • Pediatric Nutrition
  • Endocrinology
  • Public Health

Background:

  • Children with clefts often experience nutrient deficiencies.
  • Vitamin D levels in children with clefts remain under-researched compared to the general population.

Purpose of the Study:

  • To compare serum Vitamin D levels in children with clefts to an age-matched control group.
  • To assess the risk of Vitamin D insufficiency in children with clefts.

Main Methods:

  • Serum Vitamin D levels were measured in children (≤12 years) with clefts and controls from Sub-Himalayan and Gangetic Plain regions.
  • Non-parametric tests and bivariate logistic regression were used for statistical analysis.

Main Results:

  • Children with clefts exhibited significantly lower serum Vitamin D levels (P=0.02) compared to the control group.
  • The age-adjusted odds ratio for Vitamin D insufficiency in cleft patients was 2.819.

Conclusions:

  • Vitamin D deficiency is prevalent in the Sub-Himalayan region, with children with clefts being more severely affected.
  • Further trials are recommended to explore Vitamin D supplementation adjustments for children with clefts to support healing and development.

Keywords:
cleft lipcleft palatefeedinggeneticsnutrition

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