Related Experiment Video

Updated: May 10, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

18.9K

Soluble Fibrin Monomer Complex and D-Dimer Concentrations Between Patients at Low and High Risk of Venous

Anh Dinh Bao Vuong1, Ngoc Hai Tran2, Thanh Hai Pham2

  • 1Department of High-Risk Pregnancy, Tu Du Hospital, Ho Chi Minh City 71012, Vietnam.

Journal of Clinical Medicine
|March 17, 2025
PubMed

Insights

Soluble fibrin monomer complex and D-dimer tests show no significant difference in pregnant women categorized by venous thromboembolism (VTE) risk. Individualized assessment based on maternal characteristics is recommended for VTE risk evaluation.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Maternal Health

Background:

  • Venous thromboembolism (VTE) is a significant contributor to maternal mortality, with increased concern post-COVID-19 pandemic.
  • The Royal College of Obstetricians and Gynecologists (RCOG) developed a risk assessment score to mitigate thrombotic complications in pregnancy.
  • Soluble fibrin monomer complex (SFMC) is emerging as a potential alternative to D-dimer (DD) for VTE risk assessment.

Purpose of the Study:

  • To compare soluble fibrin monomer complex (SFMC) and D-dimer (DD) concentrations between low- and high-VTE-risk pregnant women.
  • To evaluate the utility of SFMC and DD in VTE risk stratification according to RCOG guidelines.

Main Methods:

  • An observational study involving 100 pregnant women (beyond 28 weeks gestation) stratified into low (≤2 points) and high (≥3 points) VTE risk groups based on RCOG guidelines.
  • Blood samples were collected pre-delivery for SFMC and DD testing.
  • Statistical analysis was performed to compare biomarker concentrations between groups, with p < 0.05 considered significant.

Main Results:

  • No statistically significant difference was observed in DD and SFMC levels between the low- and high-VTE-risk groups (p > 0.05).
  • The high-risk group experienced longer hospital stays and postpartum infections.
  • No significant correlation was found between gestational age and SFMC or DD levels, though a moderate positive correlation existed between SFMC and DD.

Conclusions:

  • SFMC and DD levels do not significantly differ between low- and high-VTE-risk pregnant women as determined by RCOG guidelines.
  • Fibrin-linked tests require individualized application, considering maternal and pregnancy characteristics for VTE risk assessment.
  • Further research with larger cohorts is necessary to validate these findings.

Keywords:
D-dimerRCOGhigh-risk pregnancymaternal mortalitysoluble fibrin monomer complexvenous thromboembolism

More Related Videos

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.1K
Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

6.7K

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...