Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

476
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
476
Glomerular Filtration01:15

Glomerular Filtration

4.7K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
4.7K
Renal Corpuscle01:20

Renal Corpuscle

6.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.9K
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

19.9K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
19.9K
Nephrons01:10

Nephrons

6.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
6.3K
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

5.0K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Light-Induced Anion Translocation to Control Helical Folding in an Artificial Communication System.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Visible-Light Sensitized Isomerization in the Lipid Bilayer Enables Activation of a Transmembrane Transporter.

Angewandte Chemie (International ed. in English)·2026
Same author

Light-Driven Supramolecular Pumping by Changing Shape Complementarity.

Journal of the American Chemical Society·2026
Same author

Hemi-Indigiosin: A pH and Red-Light Responsive Transmembrane HCl Transporter.

Angewandte Chemie (International ed. in English)·2025
Same author

Light and protonation-controlled complex formation between sulfate ions and a stiff-stilbene based bis(cyclopeptide).

Chemical science·2025
Same author

Single-Wavelength Visible-Light-Induced Reversible Isomerization of Stiff-Stilbene under Dynamic Covalent Control.

Organic letters·2025
Same journal

Pressure-Related Challenges and Strategic Approaches in Lithium Metal Sulfide all-Solid-State Batteries.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Dual Regulatory Functions of Classical Zinc Finger Clusters from Myeloid Zinc Finger-1.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

A Selectfluor-based Polonovski Rearrangement Leading to Novel Entities for Synthetic and Medicinal Applications.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Relay Approach: A Convergent Synthesis of Key Fragments en route to (+)-Neosorangicin A.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Working Under Pressure: Empirical Findings on the Challenges Facing PhD Students in Chemistry.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Charge Resonance Interaction in Aromatic Trimer Radical Cations Revealed by IR Spectroscopy: The Case of Pyrrole Homo- and Heterotrimers.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Nephrotic Syndrome I : Introduction
01:24

Nephrotic Syndrome I : Introduction

Published on: June 19, 2025

476

A Photoswitchable Chloride-Binding [2]Rotaxane.

Jorn de Jong1, Sander J Wezenberg1

  • 1Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 17, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a light-responsive anion receptor using a rotaxane structure. This molecular switch controls chloride binding and release, paving the way for novel supramolecular pumps and separation technologies.

Keywords:
anion bindingmolecular switchesphotochromismrotaxanesstiff‐stilbene

More Related Videos

Glomerular Filtration
01:15

Glomerular Filtration

4.7K
Renal Corpuscle
01:20

Renal Corpuscle

6.9K

Related Experiment Videos

Last Updated: Jan 10, 2026

Nephrotic Syndrome I : Introduction
01:24

Nephrotic Syndrome I : Introduction

Published on: June 19, 2025

476
Glomerular Filtration
01:15

Glomerular Filtration

4.7K
Renal Corpuscle
01:20

Renal Corpuscle

6.9K

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Chemical Engineering

Background:

  • Controlling anion receptor binding properties with external stimuli is crucial for applications like separation and transport.
  • Developing selective and high-affinity anion receptors responsive to light remains a significant challenge.

Purpose of the Study:

  • To design and synthesize a light-responsive anion receptor with tunable binding affinity and selectivity.
  • To investigate the potential of mechanically interlocked molecules (rotaxanes) as platforms for photoswitchable ion recognition.

Main Methods:

  • Incorporation of a stiff-stilbene photoswitch into a chloride-binding [2]rotaxane macrocycle.
  • Utilizing UV-Vis and proton nuclear magnetic resonance (¹H NMR) spectroscopy to monitor isomer interconversion and chloride binding.
  • Investigating photoswitching behavior in the presence and absence of chloride ions.

Main Results:

  • Demonstrated reversible Z/E isomer transformation of the stiff-stilbene unit upon light irradiation.
  • Observed light-induced changes in the rotaxane's motional dynamics and chloride binding affinity.
  • Confirmed photoswitching in the presence of chloride, leading to concomitant ion uptake and release.

Conclusions:

  • Rotaxane-based structures are suitable for creating light-responsive anion receptors.
  • The developed system serves as a prototype for advanced supramolecular pumps capable of controlled ion transport.
  • This work highlights the potential of photoswitchable rotaxanes in separation science and molecular machinery.