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Updated: Jan 10, 2026
Nephrotic Syndrome I : Introduction
Published on: June 19, 2025
A Photoswitchable Chloride-Binding [2]Rotaxane
Jorn de Jong1, Sander J Wezenberg1
1Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Abstract:
Control over the binding properties of anion receptors by external stimuli can be advantageous in various applications such as extraction and transport processes. Toward a light-responsive anion receptor with high binding affinity and selectivity, a stiff-stilbene photoswitch is incorporated into the macrocycle of a mechanically interlocked, chloride-binding [2]rotaxane structure. UV-Vis and 1H NMR studies show reversible transformation between Z/E-isomers upon light irradiation, causing changes in motional dynamics and binding affinity. Photoswitching also takes place in the presence of chloride, as monitored by 1H NMR spectroscopy, which results in its concomitant uptake and release. Our results show the suitability of rotaxanes as light-responsive ion receptors, which could serve as prototypes for supramolecular pumps.
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