Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

366
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
366
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K
The Thyroid Gland01:23

The Thyroid Gland

3.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.4K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.1K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.1K
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

1.4K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.4K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Meridian-Dependent Geometric Planning for Pars Plana Scleral Fixation: An Orientation-Adjusted Analytical Model.

Diagnostics (Basel, Switzerland)·2026
Same author

The Correlation Between the Presence of <i>BRAF<sup>V600E</sup></i> and <i>TERT</i> Promoter Mutation and the Response to Treatment with Iodine 131 in Differentiated Thyroid Cancer Patients.

Genes·2026
Same author

Hypotony-Free Closure of Infusion Sclerotomy Using a Slit-Modified Trocar in 23-Gauge Vitrectomy for Proliferative Diabetic Retinopathy.

Bioengineering (Basel, Switzerland)·2026
Same author

Personalized 3D-Printed Hybrid PDMS and PEEK Implants for Revisional Orbitomaxillary Reconstruction: A Translational Case-Based Technical Note.

Journal of functional biomaterials·2026
Same author

Prospective Monitoring of Serum Values of CBC, Total IgE, Thyroid Findings, D-Dimer, Vitamin D, and Inflammatory Molecules CRP, ESR, and IL-6 and Clinical Features of Chronic Spontaneous Urticaria Patients During Antihistamine Treatment.

International journal of molecular sciences·2026
Same author

Durability of Exercise vs. Revascularization in Intermittent Claudication: An Updated Meta-Analysis of Randomized Trials Focusing on Patient-Centered Outcomes.

Healthcare (Basel, Switzerland)·2026

Related Experiment Video

Updated: May 21, 2025

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
09:42

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

Published on: June 7, 2017

11.4K

Hashimoto's Thyroiditis and Dry Eye Disease.

Karla Ranđelović1,2, Tomislav Jukić3, Andrea Tešija Kuna4

  • 1Department of Ophthalmology, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, Croatia.

Journal of Clinical Medicine
|March 17, 2025
PubMed
Summary

Dry eye disease is common in Hashimoto's thyroiditis patients. Elevated IL-6 levels in tears may indicate HT-associated dry eye, with lissamine green staining and LIPCOF being useful diagnostic markers.

Keywords:
Hashimoto’s thyroiditisbiomarkersdry eye disease

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.5K
Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways
05:26

Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways

Published on: April 12, 2024

1.2K

Related Experiment Videos

Last Updated: May 21, 2025

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
09:42

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

Published on: June 7, 2017

11.4K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.5K
Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways
05:26

Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways

Published on: April 12, 2024

1.2K

Area of Science:

  • Ophthalmology
  • Immunology
  • Endocrinology

Background:

  • Hashimoto's thyroiditis (HT) is an autoimmune thyroid disease.
  • Autoimmune processes in HT can affect other organs, including the lacrimal gland.
  • Dry eye disease (DED) is a potential ocular manifestation of HT.

Purpose of the Study:

  • To analyze tear biomarkers in patients with Hashimoto's thyroiditis.
  • To explore correlations between tear biomarkers and clinical ocular parameters in HT patients.
  • To investigate the specific role of certain cytokines and enzymes in HT-associated DED.

Main Methods:

  • Comparative study involving 150 participants: HT group (N=50), non-HT DED group (N=50), and healthy controls (N=50).
  • Ocular surface assessments included OSDI, TBUT, LFC, Schirmer test, and staining (lissamine green, fluorescein).
  • Tear samples analyzed for cytokines (IL-1β, TNF-α, IL-6, IL-8, IL-10, IL-17A) and MMP-9 using ELISA and multiplex immunoassay.

Main Results:

  • DED prevalence exceeded 50% in the HT group, with severe symptoms in 48.15% of DED HT subgroup.
  • Significantly elevated IL-6 levels were found in the DED HT subgroup compared to non-HT DED (p=0.010), suggesting HT specificity.
  • Significantly lower IL-10 levels (p=0.008) and higher lissamine green staining and LIPCOF (p<0.001) were observed in the DED HT subgroup.

Conclusions:

  • DED is prevalent in euthyroid HT patients, even without thyroid-associated orbitopathy (TAO).
  • Elevated tear IL-6 may serve as a specific biomarker for HT-associated DED.
  • Lissamine green staining and LIPCOF are valuable for assessing ocular surface status in DED HT patients.