Geriatric Assessment in Older Patients with Advanced Kidney Disease: A Key to Personalized Care and Shared

Elisabeth J R Litjens1, Melanie Dani2, Wouter R Verberne3

  • 1Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands.

PubMed

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
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Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
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Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
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