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Mahmoud Marzouk1, Aymen Adhoum1, Azza Ben Yedder1
1Department of Anaesthesia and Intensive Care, National Institute of Neurology of Tunis, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
La Tunisie Medicale
|March 17, 2025
Summary
Renal resistance index (RRI) measured by ultrasound can predict acute kidney injury (AKI) in patients with septic shock. Higher RRI values indicate an increased risk of developing AKI, aiding in early detection and management.
Area of Science:
- Nephrology
- Critical Care Medicine
- Medical Imaging
Background:
- Acute kidney injury (AKI) is a common complication of septic shock.
- Bedside ultrasound measurement of renal resistance index (RRI) offers a method to assess renal hemodynamics.
Purpose of the Study:
- To investigate the variability of RRI during septic shock.
- To determine the correlation between RRI and the occurrence of AKI.
Main Methods:
- Prospective observational study of 40 patients in septic shock on mechanical ventilation.
- RRI was measured daily for the first five days of shock.
- Patients were categorized into AKI (+) and AKI (-) groups.
Main Results:
- Mean RRI was 0.704; higher in the AKI (+) group (0.757) than the AKI (-) group (0.672; p=0.013).
- RRI predicted AKI occurrence with an AUC of 0.75 (p=0.007).
- Optimal cut-off RRI for AKI prediction was 0.71 (sensitivity 73%, specificity 64%).
Conclusions:
- RRI assessment is a valuable tool for predicting AKI in septic shock patients.
- RRI may complement conventional markers for early AKI detection.
- Further validation of RRI could guide renal protection strategies in septic shock management.