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Updated: May 21, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Impact of Embedded Interdisciplinary Heart Failure Teams on Achieving Guideline-Directed Medical Therapy Within
Jessica Bregier1, Rebekah Krupski1, Stormi Gale2
1Novant Health Heart & Vascular Institute, Charlotte, NC.
Background:
Guideline-directed medical therapy (GDMT) for patients with heart failure with reduced ejection fraction (HFrEF) is under-prescribed. Real-world data regarding contemporary GDMT prescribing and the impact of scalable interdisciplinary heart failure (HF) teams are needed.
Methods And Results:
We retrospectively identified 2121 patients with HFrEF seen in 2022 in 4 community-based cardiology-practice sites that contained an embedded interdisciplinary HF team. After excluding 203 patients with missing data or encounters, GDMT prescribing was compared among those with (n = 1029) and without (n = 889) the support of the interdisciplinary HF teams. Patients were 33% female, 34% Black/African American, with an average age of 69 years. Patients seen by interdisciplinary HF teams achieved more comprehensive GDMT regimens compared to patients receiving routine care alone, as shown by higher 4-Pillar Intensification Scores (6.5 vs 4.7; P < 0.001). Using multivariable logistic regression models, patients whose care included an interdisciplinary HF team had higher odds (OR; 95% CI) of receiving sodium-glucose cotransporter-2 inhibitors (SGLT2is) (3.08; 2.37-3.99), angiotensin receptor/neprilysin inhibitors [ARNis] (1.84; 1.45-2.35) and mineralocorticoid receptor antagonists (MRAs) (1.41; 1.11-1.8) than patients receiving routine care alone.
Conclusions:
Access to embedded interdisciplinary HF teams within community cardiology practices was associated with improved GDMT prescribing, supporting broader adoption of interdisciplinary care models for optimizing GDMT.
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