Effects of Combined Hormonal Contraceptives (CHCs) on Bone Health in Adolescent Girls-A Systematic Review
Leek Mei Lim1, Wogud Ben Said2, Pallavi Latthe1
1Department of Gynaecology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom.
Objective:
To summarize the effects of combined hormonal contraceptives (CHCs) on bone health in adolescent girls DESIGN: A systematic search was performed using the following databases: Medline, EMBASE, CINAHL, and Cochrane Library clinical trials register, from inception to July 2024.
Eligibility:
Intervention and cohort studies that assessed the use of CHCs on bone health in adolescent girls aged 10-19 years old were included.
Data Synthesis:
Four randomized control trials and 8 observational studies (n = 2689) were included.
Conclusion:
Current evidence indicates that the use of CHCs in postmenarchal adolescent girls reduces bone accrual compared with non-users. The negative impact on bone accrual is likely related to the estrogen dose in the CHC preparation, the regimen used, and the duration of use.
Prospero Registration Number:
PROSPERO CRD 42024574905 on 31 July 2024.
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