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Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps
1Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems, Krems an der Donau, Austria.
Planta Medica
|March 17, 2025
Summary
This review highlights the growing interest in herbal medicine for Mpox treatment. While computational studies show promise for natural compounds, further research is needed for clinical application.
Area of Science:
- Virology
- Pharmacognosy
- Computational Biology
Background:
- Global Mpox spread necessitates novel therapeutic strategies.
- Herbal medicine has a history of treating infectious diseases.
- Evidence-based phytotherapy for Mpox requires further investigation.
Purpose of the Study:
- To review existing literature on phytotherapy for Mpox.
- To identify natural compounds with potential efficacy against Mpox.
- To address gaps in evidence-based herbal interventions for Mpox.
Main Methods:
- Comprehensive literature search of Scopus, PubMed, Cochrane, and grey literature up to August 2024.
- Analysis of publication characteristics, compounds, herbal plants, and antiviral effects.
- Inclusion of 37 articles, focusing on computational and in vitro studies.
Main Results:
- Research on Mpox phytotherapy has increased significantly since 2011, peaking in 2023.
- Most studies originated from Southeast Asia, focusing on polyphenols as lead compounds.
- Predominance of in silico (84%) and in vitro (11%) studies, with no in vivo or clinical trials.
Conclusions:
- Growing interest in phytotherapy for Mpox is evident, driven by computational research.
- Polyphenols show potential as antiviral agents against Mpox.
- Further in vitro, in vivo, and clinical studies are crucial to translate findings into practical Mpox treatments.
