Phase-lagged tACS between executive and default mode networks modulates working memory

Transcranial alternating current stimulation (tACS) is an efficient neuromodulation technique to enhance cognitive function in a non-invasive manner. Using functional magnetic resonance imaging, we investigated whether a cross-frequency coupled tACS protocol with a phase lag (45 and 180 degrees) between the central executive and the default mode networks modulated working-memory performance. We found tACS-phase-dependent modulation of task performance reflected in hippocampal activation and task-related functional connectivity. Our observations provide a neurophysiological basis for neuromodulation and a feasible non-invasive approach to selectively stimulate a task-relevant deep brain structure. Overall, our study highlights the potential of tACS as a powerful tool for enhancing cognitive function and sheds light on the underlying mechanisms of this technique.