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Satellite DNA Amplification in Advanced Prostate Cancer Is Largely Independent From Euchromatic and Oncogene
Anja Weise1, Antonio Augusto Ornellas2, Gilda Alves3
1Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
Abstract:
Recently, we were able to show that satellite DNA amplification (satDNA-AMP) is present in advanced prostate cancer. A chromosome microarray study provided first evidence that satDNA-AMP appears to be largely independent of centromere-near/pericentric euchromatic copy number alterations. Therefore, it might be carefully suggested that satDNA-AMP could be a new and independent marker for advanced tumor progression.

