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Moderate ethanol exposure disrupts energy homesotasis between central and peripheral system in APP/PS1 mice
Shinwoo Kang1,2, Jeyeon Lee3,4, Paul H Min3
1Department of Molecular Pharmacology and Experimental Therapeutics, Rochester, MN, 55905, USA. ksw90@sch.ac.kr.
Abstract:
To investigate the effects of moderate ethanol exposure on glucose metabolism in APP/PS1 mice, an early-onset Alzheimer's disease (AD) mouse model, we employed an fluoro-deoxy-glucose (FDG)-micro-positron emission tomography (PET). We also utilized the comprehensive lab animal monitoring system (CLAMS) to measure whole-body energy expenditure and respiratory exchange ratio (RER). We found that ethanol exposure increased glucose metabolism in the brain as measured by FDG-PET. Also, CLAMS data indicated a decrease in RER, suggesting a shift toward fat utilization as the primary energy source. Following ethanol exposure in APP/PS1 mice, these findings reveal a distinct metabolic difference between brain and peripheral tissues.
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