South African Propolis: Anti-Helicobacter pylori Activity, Chemistry, and Toxicity
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View abstract on PubMed
Summary
This summary is machine-generated.South African propolis exhibits potent antimicrobial activity against Helicobacter pylori, a common gut pathogen. This natural bee product shows promise for treating H. pylori infections with no observed toxicity.
Area Of Science
- Pharmacology and Microbiology
- Natural Product Chemistry
Background
- Propolis, a bee-derived resin, is known for its antimicrobial properties.
- Helicobacter pylori is a significant gastrointestinal pathogen.
- The antimicrobial potential of South African propolis against H. pylori remained uninvestigated.
Purpose Of The Study
- To evaluate the antimicrobial activity of South African propolis extracts against H. pylori.
- To assess the toxicity of these propolis extracts.
- To identify key chemical compounds responsible for the observed anti-H. pylori activity.
Main Methods
- Collection and ethanolic extraction of 51 South African and 3 Brazilian propolis samples.
- Antimicrobial broth microdilution assay to determine minimum inhibitory concentrations (MICs) against clinical H. pylori strains.
- Brine shrimp lethality assay for toxicity assessment and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) for chemical profiling.
Main Results
- 27 South African propolis extracts demonstrated superior antimicrobial activity against H. pylori compared to Brazilian samples (MIC ≤ 0.51 mg/mL).
- Pinocembrin, 3-O-acetylpinobanksin, and pinobanksin were identified as the most abundant compounds in active extracts.
- All tested propolis extracts were found to be non-toxic in the brine shrimp lethality assay (mortality < 50%).
Conclusions
- South African propolis possesses significant in vitro antimicrobial potential against Helicobacter pylori.
- Specific compounds like pinocembrin derivatives are likely responsible for the observed anti-H. pylori effects.
- Propolis represents a promising natural agent for the development of treatments for H. pylori infections.
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