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Updated: May 21, 2025
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
Case Report: Siblings with neonatal lupus erythematosus
Pengyue Tang1, Huan Zhang2, Ping Li1
1Department of Dermatology, Shenzhen Children's Hospital, Shenzhen, China.
Neonatal lupus erythematosus (NLE) can present differently even in siblings. Early diagnosis and monitoring are crucial for managing this rare autoimmune disorder in infants born to mothers with specific antibodies.
Area of Science:
- Autoimmune disorders
- Pediatric dermatology
- Maternal-fetal medicine
Background:
- Neonatal lupus erythematosus (NLE) arises from transplacental antibody transfer (anti-SSA/Ro, anti-SSB/La).
- It typically manifests with skin or cardiac issues in newborns.
- Rising multiple birth rates necessitate awareness of NLE risks.
Observation:
- Two siblings presented with distinct NLE phenotypes.
- Case 1: A female infant with classic annular skin lesions and positive SSA/SSB antibodies.
- Case 2: Her brother developed atypical red papules with similar antibody findings years later.
Findings:
- Neither sibling had systemic or cardiac involvement.
- Maternal Sjögren's syndrome and inconsistent treatment adherence were noted.
- NLE phenotype variability exists even within the same family.
Implications:
- Highlights the importance of early NLE diagnosis and management.
- Emphasizes close monitoring of antibody titers, ECGs, and echocardiograms in high-risk pregnancies.
- Underscores the need for proactive strategies in pregnancies with SSA/SSB antibodies.
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