Breaking barriers in cancer diagnosis: unveiling the 4Ms of biosensors

Cancer, an insidious affliction, continues to exact a heavy toll on humanity, necessitating early detection and nuanced comprehension of its intricacies for effective treatment. Recent strides in micro and nanoscale electronic chip fabrication have revolutionized biosensor technology, offering promising avenues for biomedical and telemedicine applications. Micro Electromechanical System (MEMS)-based integrated circuits (ICs) represent a paradigm shift in detecting chemical and biomolecular interactions pertinent to cancer diagnosis, supplanting conventional methodologies. Despite the wealth of research on biosensors, a cohesive framework integrating Material, Mechanism, Modeling, and Measurement (4M) dimensions is often lacking. This review aims to synthesize these dimensions, exploring recent breakthroughs in biosensor design and development. Categorized based on electromechanical integration, material selection, and fabrication processes, these biosensors bridge crucial knowledge gaps within the research community. A comparative analysis of sensing methods in point-of-care (PoC) technology provides insights into their practicality and efficacy. Moreover, we critically evaluate biosensor limitations, pivotal in addressing challenges hindering their global commercialization.